Psychedelic Experience May Not Be Required For Psilocybin’s Antidepressant-like Benefits

Psychedelic experience may not be required for psilocybin’s antidepressant-like benefits

Researchers have shown that psilocybin -- the active chemical in 'magic mushrooms' -- still works its antidepressant-like actions, at least in mice, even when the psychedelic experience is blocked. The new findings suggest that psychedelic drugs work in multiple ways in the brain and it may be possible to deliver the fast-acting antidepressant therapeutic benefit without requiring daylong guided therapy sessions.
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Profound Loss Of Pleasure Related To Early-onset Dementia

Profound loss of pleasure related to early-onset dementia

Loss of the ability to experience pleasure - or anhedonia - has been revealed as a key feature in frontotemporal dementia, in contrast to Alzheimer's disease. The findings from brain scans, believed to be a first, show grey matter deterioration in the so-called pleasure system of the brain - these regions were distinct from those implicated in depression or apathy, suggesting a possible treatment target for the early-onset dementia that affects people from 40-65 years.
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Blood Test For Depression, Bipolar Disorder

Blood test for depression, bipolar disorder

Worldwide, 1 in 4 people will suffer from a depressive episode in their lifetime. While current diagnosis and treatment approaches are largely trial and error, a breakthrough study sheds new light on the biological basis of mood disorders, and offers a promising blood test aimed at a precision medicine approach to treatment.
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