The poor function of microglia, the brain's immune cells in individuals exposed to early life adversity (ELA) promotes aberrant responses to stress in adulthood that may be linked to mental illness, according to a new study. During brain development, microglia prune unnecessary synapses resulting in the formation of refined, functional circuits. Disruption of that process leaves too many synapses, changing the behavioral and hormonal responses to further stresses later in life.

A new study reports that, among youth with substance use and depression, a significant proportion show early improvements in depression during their treatment for substance use. Youth who are using cannabis less frequently prior to treatment and those without conduct disorder are more likely to experience early depression improvement.

Pharmacogenetic testing was associated with nearly a two-fold (89 per cent) increase in remission rates compared to treatment as usual in a recent clinical study.

A study that showed changes in the brain in those at risk of developing bipolar disorder raises new hopes about early intervention.

Pregnant women with anorexia are at greater risk of having a stillbirth, underweight baby or pre-term birth, yet there are no clear guidelines for how doctors should manage the condition, according to a new study. Researchers have developed recommendations and principles for multidisciplinary management of anorexia nervosa in pregnancy. These recommendations include a focus on the specialist mental health, obstetric, medical, and nutritional care required to ensure optimal outcomes for women and their infants.

Regular physical activity had nearly doubled the cardiovascular benefit in individuals with depression or anxiety, compared with individuals without these diagnoses, according to a new study.

Children of mothers with clinical depression are at three times greater risk to develop depression themselves than are their low-risk peers. Researchers are working to understand the neural underpinnings of the risk, and some studies have shown altered brain processing of reward in at-risk children as young as 6. An outstanding question remains as to whether children with a maternal history of depression have a biological predisposition to blunted neural reward responding or whether it depends more on social factors. Now, new work finds those dampened responses depended on maternal feedback, suggesting the latter.

The pandemic left many GPs around the world feeling depressed, anxious and in some cases burned out, a review of global studies has revealed.

First manufactured more than 50 years ago, ketamine is a fast-acting dissociative anesthetic often used in veterinary and emergency medicine. Ketamine also has a history of being an illicit party drug. Now, ketamine is getting a closer look.

Researchers have discovered a small group of brain cells in the claustrum that controls stress-induced anxiety behaviors. Manipulating the activity of these cells also altered anxiety-related behaviors, which suggested that these claustrum cells are key to the pathogenesis of stress-related mental disorders. Furthermore, this group of cells may be considered a new target for the treatment of stress-related conditions.