Side effects mild, brief with single antidepressant dose of intravenous ketamine

Researchers found that a single, low-dose ketamine infusion was relatively free of side effects for patients with treatment-resistant depression. Widespread off-label use of intravenous subanesthetic-dose ketamine has raised concerns about side effects, especially given its history as a drug of abuse. The most common short-term side effect of the rapid-acting treatment was ‘feeling strange or loopy.’