Croton lechleri has not been shown to treat cancer in humans.
The dark red sap of C. lechleri, a tree found in many regions of South America, has been used in traditional medicine for wound healing and gastric ulcers. SP-303, a mixture of proanthocyanidin oligomers derived from the plant, was found effective in the treatment of traveler’s diarrhea and diarrhea experienced by AIDS patients.Now known as crofelemer, it is has been approved by the FDA to treat AIDS-associated diarrhea.
Studies done in animals showed that C.lechleri reduced the size of gastric ulcers and also decreased the time required for wound healing but human data are lacking. Laboratory studies indicate that it can kill cancer cells, but no studies have been done in humans.
To treat diarrhea
Clinical trials have shown that C. lechleri is effective in the treatment of traveler’s diarrhea and the diarrhea experienced by AIDS patients
To treat cancer
Laboratory studies showed that C. lechleri can kill cancer cells but human data are lacking
To treat viral infections
One clinical trial found that C. lechleri, used topically, was no more effective than placebo in treating recurrent genital herpes lesions in AIDS patients
To treat gastric ulcers
Animal studies have shown that C. lechleri can reduce the size of gastric ulcers, but there are no human studies
For wound healing
There are no studies in humans that support this use, but animal studies have shown that C. lechleri can decrease the time required for wound healing
Do Not Take If
If you are taking Dacomitinib: Crofelemer was reported to worsen dacomitinib-induced diarrhea in mice. Clinical relevance is not known.
Croton lechleri is a tree that is found in many regions of South America (1). Its dark red viscous latex, also known as Sangre de Grado or Dragon’s blood, has been used in traditional medicine for diarrhea and wound healing. In vitro and animal studies show that it can promote the healing of gastric ulcers (8) and inhibit cutaneous neurogenic inflammation (15).
A mixture of proanthocyanidin oligomers isolated from the latex of C. lechleri has shown benefits for the treatment of travelers’ diarrhea (2), and diarrhea experienced by AIDS patients (3)(18). Named crofelemer, it has been approved by the FDA as a prescription drug to relieve diarrhea associated with antiretroviral therapy in AIDS patients (17). A clinical trial is underway to determine feasibility and tolerability of crofelemer for preventing diarrhea in breast cancer patients receiving trastuzumab, pertuzumab, and docetaxel or paclitaxel (THP), or trastuzumab, pertuzumab, docetaxel, and carboplatin (TCHP) (19).
In other studies, crofelemer was reported to be no more effective than placebo in AIDS patients with recurrent genital herpes (14), while topical use of a cream containing C. lechleri resin and pomegranate seed oil was found useful in preventing and improving skin changes associated with striae distensae (dermal scarring) (20).
C. lechleri demonstrated apoptotic effects in cancer cells (4). However, it also increased the viability of leukemic cells (5). Further research is needed to determine the anticancer potential.
Mechanism of Action
SP-303, a mixture of proanthocyanidin oligomers, was shown to inhibit cAMP-mediated chloride secretion in two intestinal epithelial cell lines (Caco-2 and T84) (6)(7). The dual inhibitory action of crofelemer, a purified proanthocyanidin oligomer, on two structurally unrelated prosecretory intestinal Cl(-) channels may account for the intestinal antisecretory activity (16). The sap of C. lechleri also decreased capsaicin mediated chloride secretion (8) by inhibiting activation of sensory afferent nerves. In another study, it irreversibly altered the microtubule structure of cancer cells, rendering them incapable of adhering and in turn inducing cell death via apoptosis (4). It also inhibited the mutagenicity of 2-Aminoanthracene, although the mechanism is unknown (10). Topical application of Taspine, an alkaloid derived from C. lechleri sap, to a wound site produced an increase in wound healing activity (11) and an increase in the wound tensile strength 5-7 days following injury (12). Taspine promotes wound healing via increase in migration of fibroblasts to the wound site (11) by acting as a chemotactic factor for fibroblasts (12).
Dacomitinib: Crofelemer was reported to worsen dacomitinib-induced diarrhea in a murine model. Clinical relevance is not known (21).
Jones K. Review of sangre de drago (Croton lechleri)—a South American tree sap in the treatment of diarrhea, inflammation, insect bites, viral infections, and wounds: traditional uses to clinical research. J Altern Complement Med 2003;9(6):877-96.