Children with long-term health conditions may be more likely to experience mental illness in early adolescence than healthy children, according to new research.

Researchers have discovered a neural circuit that drives physical responses to emotional stress. Emotional stress signals are processed in the ''emotion'' circuits and integrated in the DP/DTT. The integrated signals are transmitted to the hypothalamus which then drives a variety of physical responses through circuits that control ''body'' functions. The discovered ''mind-body'' connection constitutes a key part of the stress circuit in the brain.

Researchers found that similar factors cause both medical intern burnout and depression. These findings can be used to identify and treat burnout as well as mitigate the risk of burnout by modifying workplace factors.

Researchers have discovered a deficiency in the brains of people with schizophrenia that could lead to the development of new drug therapies. A postmortem comparison revealed that schizophrenia was associated with lower than normal levels of S1P, a type of fatty molecule found in the white matter of the brain.

Children who experience trauma, abuse, neglect and family dysfunction are at increased risk of having heart disease in their 50s and 60s. People exposed to the highest levels of childhood family environment adversity were more than 50% more likely to have a cardiovascular disease event such as a heart attack or stroke over a 30-year follow-up.

New research finds that children's rearing environment has a meaningful impact on their risk for major depression later in life, and notes the importance supporting of nurturing environments when children are at risk.

Mood varies from hour-to-hour, day-to-day and healthy mood regulation involves choosing activities that help settle one's mood. However, in situations where personal choices of activities are constrained, such as during periods of social isolation and lockdown, this natural mood regulation is impaired which might result in depression. New research suggests a new target for treating and reducing depression is supporting natural mood regulation.

A new study finds adults with traumatic spinal cord injury are at an increased risk of developing mental health disorders and secondary chronic diseases compared to adults without the condition.

Ketamine alleviates depressive symptoms within hours, with the most significant change typically seen a day after its administration. However, the symptoms often reappear within a week. According to researchers, neural connections strengthened by the quick treatment of depression are consolidated in the brain during the deep sleep periods of the following night. To prevent the circle of negative thoughts regaining supremacy, depressed patients also need therapy.

Researchers have found that a novel class of genes known as long non-coding RNAs (lncRNAs) expressed in the brain may play a pivotal role in regulating mood and driving sex-specific susceptibility versus resilience to depression.