Landmark study implicates specific genes in schizophrenia

The largest ever genetic study of schizophrenia has identified large numbers of specific genes that could play important roles in the psychiatric disorder. A group of hundreds of researchers across 45 countries analysed DNA from 76,755 people with schizophrenia and 243,649 without it to better understand the genes and biological processes underpinning the condition. The new study found a much larger number of genetic links to schizophrenia than ever before, in 287 different regions of the genome, the human body's DNA blueprint.
Read More

Early life adversity, microglia dysfunction linked to aberrant adult stress responses, mental illness

The poor function of microglia, the brain's immune cells in individuals exposed to early life adversity (ELA) promotes aberrant responses to stress in adulthood that may be linked to mental illness, according to a new study. During brain development, microglia prune unnecessary synapses resulting in the formation of refined, functional circuits. Disruption of that process leaves too many synapses, changing the behavioral and hormonal responses to further stresses later in life.
Read More