I have had chronic pain in both thumbs for the past 10 years. Some days it hurts to hold a glass. A hand specialist diagnosed me with bone on bone in both thumbs. He gave me a cortisone injection but that only helped the pain for about a week. My family practice doctor put me on Nufola daily and I have seen a huge difference! Although the pain is not completely gone, it is less hindering and I have full function in both thumbs.